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C, d).ALDH1 expression in tumor cells is not independent risk factor for overall survivalMultivariate analysis was performed using Cox Regression method based on the above clinicopathological parameters and ALDH1 expression in tumor cells and stromal cells (Table 4). Age at diagnosis, FIGO stage and differentiation grade are independent risk factor for overall survival in ovarian carcinomas (p
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Is still the most lethal gynecologic malignancy worldwide. Although most ovarian carcinoma cells are initially sensitive to chemotherapy, there is always a small population cells that always survives and initiates new tumors which causes recurrence [31]. The verification of tumor heterogeneity further enhances the hypothesis of CSCs. Compelling evidence has shown that ovarian carcinomas with enric
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Sp1GFP cells expressed low levels of epithelial (E) cadherin, which can be consis tent together with the notion that Mesp1GFP cells undergo EMT in the course of MCP specification (Fig. five C). RTPCR evaluation performed on FACSisolated CXCR4/PDGFRa/Flk1 TP cells showed that MCPs isolated using monoclonal antibodies present a related enrichment for the expression of cardiovascular transcriptional
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Nt years [32]. In their study, dual positive cells of ALDH1 and another traditional ovarian CSC marker CD133 were isolated directly from human tumor to initiate tumor in mice, and these cells displayed enhanced angiogenesis and tumorigenicity like other CSCs [32]. Moreover, the patients with CD133(+)/ALDH1(+) tumor cells displayed reduced PFS and OS [32]. Distinct expression levels and patterns of
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Arian CSCs include CD44, epithelial cell adhesion moleculeHuang et al. BMC Cancer (2015) 15:Page 6 ofTable 3 The associations of ALDH1 expression levels in stromal cells and the clinical and pathologic characteristicsALDH1 IHC score in stromal cells 1 (negative) Number Age (years old): 39 40?9 50?9 60?9 70 missing Histological subtype: Serous carcinoma Mucinous carcinoma Endometrioid carcinoma Cle
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The rise of CSC theory, some specific CSC markers were being discovered to identify putative CSCs, and ALDH1 is becoming to act as a CSC marker in the CSC studies of variable tumor types in vitro and in vivo. Epithelial-to-mesenchymal transition (EMT) is an important driver of tumor invasion and metastasis, which may be a feature of CSC. Compared to ALDH1(-) EMT cells, only ALDH1(+) EMT cells had
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The rise of CSC theory, some specific CSC markers were being discovered to identify putative CSCs, and ALDH1 is becoming to act as a CSC marker in the CSC studies of variable tumor types in vitro and in vivo. Epithelial-to-mesenchymal transition (EMT) is an important driver of tumor invasion and metastasis, which may be a feature of CSC. Compared to ALDH1(-) EMT cells, only ALDH1(+) EMT cells had
1
The rise of CSC theory, some specific CSC markers were being discovered to identify putative CSCs, and ALDH1 is becoming to act as a CSC marker in the CSC studies of variable tumor types in vitro and in vivo. Epithelial-to-mesenchymal transition (EMT) is an important driver of tumor invasion and metastasis, which may be a feature of CSC. Compared to ALDH1(-) EMT cells, only ALDH1(+) EMT cells had
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